Michael W N Deininger Selected Research

DCC-2036

5/2011	The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile.
1/2011	Targeting the BCR-ABL signaling pathway in therapy-resistant Philadelphia chromosome-positive leukemia.

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Michael W N Deininger Research Topics

Disease

40	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 11/2022 - 03/2002
10	Philadelphia Chromosome 12/2019 - 03/2003
6	Leukemia 12/2019 - 12/2003
6	Primary Myelofibrosis (Myelosclerosis) 01/2017 - 11/2005
6	Blast Crisis (Blast Phase) 12/2006 - 05/2002
5	Disease Progression 01/2017 - 03/2002
5	Neoplasms (Cancer) 11/2009 - 07/2005
4	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2018 - 11/2004
3	Chromosome Aberrations (Chromosome Abnormalities) 10/2007 - 03/2003
3	Systemic Mastocytosis 01/2006 - 12/2004
3	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 07/2005 - 02/2004
2	Fatigue 01/2021 - 01/2017
2	Diarrhea 01/2021 - 01/2017
2	Pancreatitis 12/2019 - 11/2012
2	Polycythemia Vera 01/2017 - 11/2005
2	Splenomegaly 01/2017 - 04/2015
2	Essential Thrombocythemia 01/2017 - 11/2005
2	Genetic Translocation (Chromosomal Translocation) 09/2010 - 06/2004
1	Pneumonia (Pneumonitis) 01/2017
1	Sepsis (Septicemia) 01/2017
1	Thrombocytopenia (Thrombopenia) 04/2015
1	Anemia 04/2015
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2012
1	Polycythemia (Erythrocytosis) 12/2006
1	Thrombocytosis (Thrombocythemia) 12/2006
1	Seminoma 01/2006
1	Myeloproliferative Disorders (Myeloproliferative Disorder) 11/2005
1	Residual Neoplasm 03/2005
1	Myeloid Leukemia (Leukemia, Myelocytic) 04/2003
1	Cytopenia 05/2002

Drug/Important Bio-Agent (IBA)

30	Imatinib Mesylate (Gleevec)FDA Link 01/2011 - 03/2002
15	Phosphotransferases (Kinase)IBA 12/2019 - 11/2004
7	bcr-abl Fusion ProteinsIBA 12/2006 - 03/2002
6	Tyrosine Kinase InhibitorsIBA 11/2022 - 11/2012
5	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 09/2010 - 03/2003
3	ruxolitinibIBA 01/2017 - 12/2013
3	Janus Kinase 1IBA 01/2017 - 12/2013
3	Janus Kinase 2IBA 01/2017 - 11/2005
3	ponatinibIBA 11/2012 - 11/2009
3	Dasatinib (BMS 354825)FDA Link 01/2011 - 01/2006
3	Proteins (Proteins, Gene)FDA Link 09/2010 - 09/2003
3	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2006 - 03/2003
3	Pharmaceutical PreparationsIBA 12/2005 - 05/2002
3	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 07/2005 - 11/2004
2	Lipase (Acid Lipase)FDA Link 12/2019 - 11/2012
2	DCC-2036IBA 05/2011 - 01/2011
2	nilotinib FDA Link 01/2011 - 11/2009
2	RNA (Ribonucleic Acid)IBA 09/2009 - 10/2007
2	Interferon-alpha (Interferon Alfa)IBA 12/2006 - 04/2003
2	Tyrosine (L-Tyrosine)FDA Link 11/2005 - 11/2004
1	Adenosine Triphosphate (ATP)IBA 12/2019
1	asciminibIBA 12/2019
1	Heparin (Liquaemin)FDA LinkGeneric 01/2018
1	AnticoagulantsIBA 01/2018
1	N- (cyanomethyl)- 4- (2- ((4- (4- morpholinyl)phenyl)amino)- 4- pyrimidinyl)benzamideIBA 01/2017
1	Amylases FDA Link 11/2012
1	Amino Acids FDA Link 02/2009
1	Protein Isoforms (Isoforms)IBA 01/2006
1	Codon (Codons)IBA 01/2006
1	AP23464IBA 07/2005
1	AP23848IBA 07/2005
1	fms-Like Tyrosine Kinase 3IBA 11/2004
1	tandutinibIBA 11/2004
1	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 11/2004
1	Oncogene Proteins (Oncogene Protein)IBA 06/2004
1	Proto-Oncogene Proteins c-cblIBA 12/2003
1	InterferonsIBA 04/2003
1	multidrug resistance-associated protein 1IBA 03/2003
1	Idarubicin (4 Demethoxydaunorubicin)FDA LinkGeneric 03/2003

Therapy/Procedure

18	Therapeutics 01/2018 - 05/2002
2	Drug Therapy (Chemotherapy) 01/2018 - 09/2003
2	Transplantation 12/2006 - 12/2003
1	Complementary Therapies (Alternative Medicine) 09/2009